武汉大学基础医学院

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国家“千人计划”特聘教授 -- 霍文哲

时间:2016-06-23 08:31:06  来源:  作者:  点击数:

                             霍文哲

1、职称职务:教授,博导、国家“千人计划”入选者、美国天普大学医学院病理系终身正
教授,解剖及细胞生物学系正教授

2、学科专业:病原生物学系

3、研究方向:

4、实验室位置:

5、联系电话:+86-27-68759807

6Emailwenzheho@temple.edu

7、学习经历:
2004-2006:美国宾夕法尼亚大学医学院医学卫生硕士 / M.P.H., University of Pennsylvania School of Medicine

1988-1991:美国宾夕法尼亚大学Wistar研究所分子病毒学博士后 / Postdoctoral Fellow, Molecular Virology, Wistar Institute, University of Pennsylvania

1986-1988:美国宾夕法尼亚大学医学院儿科系费城儿童医院传染及免疫科临床医学博士研究员M..D.Fellow, Division of Infectious Diseases, Children’s Hospital of Philadelphia, Department of Pediatrics,University of Pennsylvania School of Medicine

1983-1986:武汉大学人民医院儿科住院医生 / Resident, Wuhan University Renmin Hospital

1980-1983:武汉大学医学院(湖北医学院)儿科系医学硕士 / M.S., Wuhan University School of Medicine (Hubei Medical College), China

1975-1979:武汉大学医学院(湖北医学院)医学学士 / B.S., Wuhan University School of Medicine (Hubei Medical College), China


8、主要工作经历与任职
2010.09-至今:武汉大学动物实验中心/ABSL-III实验室主任、教授 / Director and Professor, Center for Animal Experiment of Wuhan University/ABSL-Ⅲ Laboratory of Wuhan University, China

2009-至今: 美国天普大学医学院病理系终身正教授,博士生导师 / Professor(Tenure), Department of Pathology and Laboratory Medicine, Temple University, USA

2009-至今: 美国天普大学医学院解剖及细胞生物系正教授 / Professor, Department of Anatomy and Molecular Biology, Temple University, USA

2002-2009: 美国宾夕法尼亚大学医学院费城儿童医院传染及免疫科病毒室主任 / Director, Virology Laboratory, Division of Infectious Diseases, Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA

2005-2009: 美国宾夕法尼亚大学医学院儿科系正教授 / Professor, Department of Pediatrics, University of Pennsylvania School of Medicine, USA

1998-2005: 美国宾夕法尼亚大学医学院儿科系副教授 / Associate Professor, Department of Pediatrics, University of Pennsylvania School of Medicine, USA

1993-1998: 美国宾夕法尼亚大学医学院儿科系助理教授 / Assistant Professor, Department of Pediatrics, University of Pennsylvania School of Medicine, USA

1991-1993: 美国宾夕法尼亚大学医学院儿科系科研研究员 / Research Associate, Department of Pediatrics, University of Pennsylvania School of Medicine, USA

 

9、目前主要科学研究领域和兴趣

研究领域:

1. 天然免疫与病毒感染机制的研究 / Innate Immunity and Viral Infections

2. 吸毒与HIV、HCV感染的研究 / Drugs of Abuse and HIV/HCV Infection

3. 天然免疫与中枢神经系统保护机制的研究 / Innate Immunity and CNS Protection

 

105年代表性论文
(1) Wang X, Ye L, Zhou Y, Liu MQ, Zhou DJ, Ho WZ. Inhibition of anti-HIV microRNA expression: a mechanism for opioid-mediated enhancement of HIV infection of monocytes. Am J Pathol. 2011;178:41-47.

(2)Li J, Ye L, Cook DR, Wang X, Liu J, Kolson DL, Persidsky Y, Ho WZ. Soybean-derived Bowman-Birk inhibitor inhibits neurotoxicity of LPS-activated macrophages.

J Neuroinflammation; 2011;8:15.

(3)Li J, Hu S, Zhou L, Ye L, Wang X, Ho J, Ho WZ. Interferon lambda inhibits herpes simplex virus type I infection of human astrocytes and neurons. Glia. 2011;59:58-67.

(4)Ye, L., Wang, X., Metzger, D.S., Riedel, E., Montaner, L.J., Ho, WZ.: Upregulation of SOCS-3 and PIAS-3 impairs IL-12-mediated interferon-gamma response in CD56 T cells in HCV-infected heroin users. PLoS One5(3):e9602, 2010.

(5)Zhou, Y., Wang, X., Liu, M., Hu, Q., Song, L., Ye, L., Zhou, D., Ho, WZ.:

A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages. Immunology. 2010 Jul 16. [Epub ahead of print]

(6)Ye L, Wang X, Wang SH, Wang YJ, Song L, Hou W, Zhou L, LI H, Ho WZ. CD56+ T cells inhibit hepatitis C virus replication in human hepatocytes. Hepatology 49:753-762. 2009.

(7)Wang X, Ye L, Hou W, Zhou Y, Wang YJ, Metzger DS, Ho WZ.Intracellular restriction factors contribute to susceptibility of monocytes and macrophages to HIV-1 infection. Blood15; 113(3):671-674, 2009.

(8)Hou W, Wang X, Ye L, Wang YJ, Zhou L, Yang ZQ, Riedel E, Ho WZ. Interferon lambda inhibits HIV-1 infection of macrophages. J Virol 83:3834-3841, 2009.

(9)Zhou L, He L, Wang X, Wang YJ, Zhou Y, Ye L, Hou W, Ho WZ. Expression, regulation and antiviral effect of IFN lambda in human neuronal cells. Neuroscience 17; 159(2):629-637, 2009.

(10)Liang H,WangW, ChenH, SongL, YeL, Wang SH, Wang YJ, HoWZ. Methamphetamine enhances human immunodeficiency virus infection of human macrophage. Am J Pathol172:1617-1624, 2008.

(11)Wang X, Ye L, Zhou Y, Hou W, Metzger D, Ho WZ. Cellular microRNAs expression correlates with susceptibility of monocyte/macrophage to HIV-1 infection. Blood 113:671-674, 2008.

(12)Li Y, Peng JS, Wang CQ, Zhang T, Wan Q, Ho WZ. Morphine inhibits intrahepatic interferon alpha expression coupled with full cycle HCV replication. J Infect Dis196:719-730, 2007.

(13) Lai, J-P., Ho, WZ., Kilpatrick, L.E., Wang, X., Kolchak, H.M., and Douglas, S.D.: Full-Length and Truncated Neurokinin-1 Receptor (NK-1R) Expression during Monocyte-Macrophage Differentiation. Proc. Natl. Acad. Sci. U. S. A. 103:7771-7776, 2006.