武汉大学基础医学院

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国家杰出青年基金获得者 、国家新世纪百千万人才工程入选者 -- 章晓联

时间:2016-06-22 10:56:27  来源:  作者:  点击数:

                         章晓联_改

1、职称职务:武汉大学基础医学院免疫学系主任,湖北省过敏及免疫相关疾病重点实验室主任。 武汉大学“珞珈学者”特聘教授,国家杰出青年基金获得者、国家百千万人才工程人选入选者。武汉大学二级教授,博导。

2、学科专业: 医学免疫学

3、研究方向: 人类重要病原微生物糖生物学与感染研究

4、联系电话: 86-27-68759986

5、Email: zhangxiaolian@whu.edu.cn

6、学习经历:

1986年获得武汉大学病毒学及分子生物学系学士;1989年获武汉大学病毒学及分子生物学系硕士;1997年获香港科技大学生物化学博士学位;1997-2001在美国U.of Maryland at College Park作博士后及研究专家;2001年作为武汉大学引进人才回到武汉大学医学院免疫系聘为教授至今。2004年赴日本福岛医科大学免疫学系作为访问学者。

7、主要工作经历与任职

国家杰出青年基金获得者,国家级百千万人才工程人选入选者,中国青年女科学家提名奖获得者(2005年)。中华医学会微生物及免疫学会副主任委员,中华医学会武汉市微生物及免疫学会副理事长, 武汉市免疫学会副理事长,中国生物化学与分子生物学学会糖复合物专业委员会委员。担任“Frontiers in Cellular and Infection Microbiology”杂志的review editor 编委; 担任“Infectious Disorders – Drug Targets'” Editorial Board Members,担任“Open Glycoscience” Editorial Board Members,以及《中国病毒学》,《中国生化药物杂志》和《武汉大学学报》英文版杂志编委

8、目前主要科学研究领域和兴趣

长期从事引起人类重要病原微生物、肿瘤表面糖苷、凝集素和糖基化免疫功能研究。 其主要成就包括:1) 首次发现人伤寒沙门菌毒力岛上一种新的致病相关的IVB型纤毛基因操纵子(含有11个基因)等基因及其功能,这些工作对阐述人伤寒沙门菌只感染人的种属特异性病因具有重要价值;2)揭示了糖苷和糖基化在感染、肿瘤免疫识别和逃逸中的关键功能;3)成功设计和研制了特异结合这些病原微生物和肿瘤细胞表面糖苷的药物分子、糖基化抑制剂和有效候选疫苗。

她主持了有关结核病分子标识和丙型肝炎病毒免疫逃逸机制研究分别获得国家“十一五”、“十二五”重大传染病专项课题、973课题等项目,研究成果发表论文122篇,SCI论文84篇,被Nature等国际权威杂志SCI他引用1000次,单篇他引最高88次,论文多次曾被FACULTY of 1000引用,评价为Top2%;获得授权发明专利23项。获中华医学奖二等奖、湖北省自然科学一等、二等奖等。国际会议大会邀请报告10余次。

9、教学情况:

承担本科生以及研究生《医学免疫学》理论和实验教学。国家教育部“医学免疫学”双语教学示范课程的负责人, 教育部来华留学生英语品牌课程负责人, 湖北省“医学免疫学”精品课程负责人。武汉大学教学名师,湖北省教学名师。

10、近5年代表性论文

(1)Zhao Y, Ren Y, Zhang X, Zhao P, Tao W, Zhong J, Li Q, Zhang XL*. (2014). Ficolin-2 inhibits Hepatitis C Virus infection, whereas apolipoprotein E3 mediates viral immune escape. J Immunol. 193(2):783-96.

(2)Pan Q, Wang Q, Sun X, Xia X, Wu S, Luo F, Zhang XL*. (2014). Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeys. Mol Ther. 22(5):940-51.

(3)Tang XL, Zhou YX, Wu SM, Pan Q, Xia B, Zhang XL*. (2014)CFP10 and ESAT6 aptamers as effective Mycobacterial antigen diagnostic reagents. J Infect. 2014 Jun 23. pii: S0163-4453(14)00167-4. doi: 10.1016/j.jinf.2014.05.015. [Epub ahead of print]

(4)Luo F, Sun X, Wang Y, Wang Q, Wu Y, Pan Q, Fang C, Zhang XL*. (2013). Ficolin-2 defends against virulent Mycobacteria Tuberculosis infection in vivo, and its insufficiency is associated with infection in humans. PloS One, 8 (9): e73859.

(5)Pan Q, Chen H, Wang F , Jeza VT , Hou W, Zhao Y, Xiang T, Zhu Y, Endo Y, Fujita T, Zhang XL* (2012). L-ficolin binds to glycoproteins HA and NA and inhibits influenza A virus infection both in vitro and in vivo. J Innate Immun 4:312-24.

(6)Chen HD, Zhou X, Yu G, Zhao YL, Ren Y, Zhou YD, Li Q, Zhang XL* (2012). Knockdown of core 1 beta 1, 3-galactosyltransferase prolongs skin allograft survival with induction of galectin-1 secretion and suppression of CD8+T cells. J Clin Immunol 32:820-836.

(7)Ning N, Pan Q, Zheng F, Teitz-Tennenbaum S, Egenti M, Yet J, Li M, Ginestier C, Wicha MS, Moyer JS, Prince ME, Xu Y, Zhang XL, Huang S, Chang AE, Li Q (2012). Cancer stem cell vaccination confers significant antitumor immunity. Cancer Res 72(7):1853-64.

(8)Chen F, Zhao Y, Liu M, Li D, Wu H, Chen H, Zhu Y, Zhong J, Zhou Y, Qi Z, Zhang XL*. (2010) Functional Selection of Hepatitis C Virus Envelope E2 Binding Peptide Ligand Using Ribosome Display. Antimicrob Agents Chemother. 54: 3355-3364. (IF:4.8)

(9)Zhong B, Zhang L, Lei C, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL, Shu HB* (2009) .The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity 30(3):397-407.

(10)Ma Y, Chen H, Wang Q, Luo F, Yan J, Zhang XL* (2009). IL-24 protects against Salmonella typhimurium infection by stimulating early neutrophil Th1 cytokine production that in turn activate CD8+ T cells. Eur J Immunol 39:3357-68.

 

Xiao-Lian Zhang

1

Academic title

/Position

Chair of Immunology Department, Director of Hubei Province Key Laboratory of Allergy and Immunology, Professor of State Key Laboratory of Virology Wuhan University School of Medicine, Wuhan 430071, China

Research Field

Infection and Immunology

Glycoimmunity

keywords of my ongoing research work

Hepatitis C Virus

Mycobacterium Tuberculosis

Lectin, pathogen surface glycans

Immune escape

Anti-infection immunity

Prof. Xiao-LianZhang has published more than 100 professional research papers. She has applied for 42 patents and 25 patents were authorized.

Selected Publications (*: corresponding author)

  1. 1. Zhao Y, Ren Y, Zhang X, Zhao P, Tao W, Zhong J, Li Q, Zhang XL*. Ficolin-2 inhibits Hepatitis C Virus infection, whereas apolipoprotein E3 mediates viral immune escape. J Immunol.2014, 193(2):783-96 , cited by F1000Prime
  2. 2. Pan Q, Wang Q, Sun X, Xia X, Wu S, Luo F, Zhang XL*. Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeys. Mol Ther. 2014, 22(5):940-51.
  3. 3. Tang XL, Zhou YX, Wu SM, Pan Q, Xia B, Zhang XL*. CFP10 and ESAT6 aptamers as effective Mycobacterial antigen diagnostic reagents. J Infect. 2014, 69: 569-580.
  4. 4. Wu SM, Ai HW, Zhang DY, Han XQ, Pan Q, Luo FL, Zhang XL*. miR-141 targets ZEB2 to suppress HCC progression. Tumour Biol. 2014, 35(10):9993-7.
  5. 5. Luo F, Sun X, Wang Y, Wang Q, Wu Y, Pan Q, Fang C, Zhang XL*. Ficolin-2 defends against virulent Mycobacteria Tuberculosis infection in vivo, and its insufficiency is associated with infection in humans. PloS One, 2013, 8 (9): e73859.
  6. 6. Yilan Hu, Fengling Luo, Junliang Fu, Tielong Chen, Shimin Wu, Yi-Dan Zhou, Xiao-Lian Zhang*. Early increased ficolin-2 concentrations are associated with severity of liver inflammation and efficacy of anti-viral therapy in chronic hepatitis C patients. Scand J Immunol 2013,77:144-150.
  7. 7. Pan Q, Chen H, Wang F , Jeza VT , Hou W, Zhao Y, Xiang T, Zhu Y, Endo Y, Fujita T, Zhang XL*L-ficolin binds to glycoproteins HA and NA and inhibits influenza A virus infection both in vitro and in vivo. J Innate Immun 2012. 4:312-24.
  8. 8. Chen HD, Zhou X, Yu G, Zhao YL, Ren Y, Zhou YD, Li Q, Zhang XL*. Knockdown of core 1 beta 1, 3-galactosyltransferase prolongs skin allograft survival with induction of galectin-1 secretion and suppression of CD8+T cells. J Clin Immunol 2012, 32:820-836.
  9. 9. Deng M, Feng S, Luo F, Wang S, Sun X, Zhou X*, Zhang XL*. Visual detection of rpoB mutations in rifampin-resistant Mycobacterium tuberculosis using an asymmetrically split peroxidase DNAzyme. J. Clin. Microbiol. 2012.50: 3443-3450
  10. 10. Ma Y, Chen Hai-Dan, Wang Yubin, Wang Qilong, Li Yingying, Zhao Yinglan, Zhang Xiao-lian*. Interleukin 24 as a novel potential cytokine immunotherapy for the treatment of Mycobacterium tuberculosis infection. Microbes Infect. 2011, 13: 1099-1110.
  11. 11. Chen F, Zhao Y, Liu M, Li D, Wu H, Chen H, Zhu Y, Zhong J, Zhou Y, Qi Z, Zhang XL*. Functional Selection of Hepatitis C Virus Envelope E2 Binding Peptide Ligand Using Ribosome Display. Antimicrob Agents Chemother. 2010, 54: 3355-3364. cited by FACULTYof1000
  12. 12. Zhong B, Zhang L, Lei C, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL, Shu HB*.The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity 2009, 30(3):397-407.
  13. 13. Ma Y, Chen H, Wang Q, Luo F, Yan J, Zhang XL* IL-24 protects against Salmonella typhimurium infection by stimulating early neutrophil Th1 cytokine production that in turn activate CD8+ T cells. Eur J Immunol 2009, 39:3357-68.
  14. 14. Chen F, Hu Y, Li D, Chen H, and Zhang XL*. CS-SELEX generates high-affinity ssDNA aptamers as molecular probes for Hepatitis C Virus envelope glycoprotein E2. PloS One, 2009, 4 (12):e8142:1-11.
  15. 15. Li DQ, Li Y, Wu X, Li Q, Yu J, Gen J, Zhang XL*. Knockdown of Mgat5 inhibits breast cancer cell growth with activation of CD4+T cells and macrophages. J Immunol 2008, 80: 3158-3165.